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KMID : 0371320050690030210
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Journal of the Korean Surgical Society
2005 Volume.69 No. 3 p.210 ~ p.216
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C-met and E-cadherin Expression in Advanced Gastric Cancer
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Oh Seung-Tak
Lee Young-Don
Hwang Yu-Jin
Suh Jae-Hwan
Lee Woon-Ki
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Abstract
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Purpose: In the current study, the relation between the clinicopathological parameters and levels of the amplification of the c-met and E-cadherin genes were investigated in patients with an advanced gastric carcinoma.
Methods: The levels of amplification of the c-met and E-cadherin genes in 44 advanced gastric carcinoma patients were retrospectively investigated using RT-PCR. The relationships between the levels of amplification of these genes and the clinicopathological parameters were evaluated using univariate and multivariate analyses.
Results: Seventeen (38.6%) and 13 (29.5%) of the 44 advanced gastric carcinoma patients were evaluated as having amplification of the c-met gene and down-regulation of the E-cadherin gene, respectivly. The amplification of c- met gene was significantly correlated with serosal invasion, lymph node metastasis and neural invasion, whereas the down-regulation of the E-cadherin gene was significantly correlated with the diffuse type of gastric carcinoma by Lauren’s calssification, and neural invasion.
Conclusion: The levels of the c-met and E-cadherin gene amplifications may be a powerful aids in evaluating the metastatic potential and prognosis in patients with advanced gastric cancer. (J Korean Surg Soc 2005;69:210-216)
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KEYWORD
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Advanced gastric cancer, C-met, E-cadherin, Clinicopathological parameters
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